Publications

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses

Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch

The GPCR adaptor protein Norbin regulates S1PR1 trafficking and the morphology, cell cycle and survival of PC12 cells

Valdemar B. I. Johansen, Elizabeth Hampson, Elpida Tsonou, Chiara Pantarelli, Julia Y. Chu, Laraine Crossland, Hanneke Okkenhaug, Andrew J. Massey, David C. Hornigold, Heidi C. E. Welch, Stephen A. Chetwynd

Functions and mechanisms of the GPCR adaptor protein Norbin

Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis

Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch

Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors

C. D. Lawson, K. Hornigold, D. Pan, I. Niewczas, S. Andrews, J. Clark, Hce Welch

Behavioural immune landscapes of inflammation

Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G. Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M. Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D. Castillo, Heidi C. E. Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E. Smithgall, Mauro Di Pilato, Thorsten R. Mempel, Pierre-Louis Tharaux, Santiago F. González, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F. Calvo, Iván González-Díaz, Fernando Díaz-De-María, Andrés Hidalgo

Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch

P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells

Elizabeth Hampson, Elpida Tsonou, Martin J. Baker, David C. Hornigold, Roderick E. Hubbard, Andrew Massey, Heidi C. E. Welch

Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C. E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis

The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection

Chiara Pantarelli, Dingxin Pan, Stephen Chetwynd, Anne-Katrien Stark, Kirsti Hornigold, Polly Machin, Laraine Crossland, Simon J. Cleary, Martin J. Baker, Elizabeth Hampson, Anna Mandel, Anne Segonds-Pichon, Rachael Walker, Cornelis Van 'T Veer, Yanira Riffo-Vasquez, Klaus Okkenhaug, Simon Pitchford, Heidi C. E. Welch

Rho Family GTPases and Rho GEFs in Glucose Homeostasis

Polly A. Machin, Elpida Tsonou, David C. Hornigold, Heidi C. E. Welch

PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, Christina A. Mitchell

Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment

Chiara Pantarelli, Heidi C. E. Welch

Removing physiological motion from intravital and clinical functional imaging data

Sean C. Warren, Max Nobis, Astrid Magenau, Yousuf H. Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James Rw Conway, Pauline Mélénec, Thomas R. Cox, Yingxiao Wang, Jennifer P. Morton, Heidi CE Welch, Douglas Strathdee, Kurt I. Anderson, Tri Giang Phan, Michael S. Roberts, Paul Timpson

P-Rex2

Elpida Tsonou, Chiara Pantarelli, Kirsti Hornigold, Heidi C. E. Welch

P-Rex1

Kirsti Hornigold, Elpida Tsonou, Chiara Pantarelli, Heidi C. E. Welch

Platelets in neutrophil recruitment to sites of inflammation

Simon Pitchford, Dingxin Pan, Heidi CE Welch

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts

Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James Rw Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian MW Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo Del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi CE Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin

Small GTPases and their guanine-nucleotide exchange factors and GTPase-activating proteins in neutrophil recruitment

Martin J Baker, Dingxin Pan, Heidi C E Welch

Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1

Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi CE Welch

Regulation and function of P-Rex family Rac-GEFs

Heidi CE Welch

The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

Marina Pajic, David Herrmann, Claire Vennin, James Rw Conway, Venessa T. Chin, Anna-Karin E. Johnsson, Heidi CE Welch, Paul Timpson

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation

Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, HeidiCE Welch

A Rac1-Independent Role for P-Rex1 in Melanoblasts

Colin R. Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M. Machesky, Owen J. Sansom

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils

George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

Anna-Karin E Johnsson, Yanfeng Dai, Max Nobis, Martin J Baker, Ewan J McGhee, Simon Walker, Juliane P Schwarz, Shereen Kadir, Jennifer P Morton, Kevin B Myant, David J Huels, Anne Segonds-Pichon, Owen J Sansom, Kurt I Anderson, Paul Timpson, Heidi C E Welch

P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments

Andrew D. Campbell, Samuel Lawn, Lynn C. McGarry, Heidi C. Welch, Bradford W. Ozanne, Jim C. Norman

Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling

Jan M. Herter, Jan Rossaint, Helena Block, Heidi Welch, Alexander Zarbock

The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α

Mark a Barber, Annick Hendrickx, Monique Beullens, Hugo Ceulemans, David Oxley, Sylvia Thelen, Marcus Thelen, Mathieu Bollen, Heidi C E Welch

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom

Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities

Yanfeng Dai, Simon A. Walker, Edwin De Vet, Simon Cook, Heidi C. E. Welch, Peter J. Lockyer

P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

Campbell D. Lawson, Sarah Donald, Karen E. Anderson, Daniel T. Patton, Heidi C. E. Welch

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

Joseph E. Aslan, Alex M. Spencer, Cassandra P. Loren, Jiaqing Pang, Heidi C. Welch, Daniel L. Greenberg, Owen Jt McCarty

Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase

Claire Jackson, Heidi C. Welch, Tomas C. Bellamy

Role of GEFs in Disease

Heidi Welch

P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

Sarah Donald, Trevor Humby, Ian Fyfe, Anne Segonds-Pichon, Simon A. Walker, Simon R. Andrews, W. John Coadwell, Piers Emson, Lawrence S. Wilkinson, Heidi C. E. Welch

Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

Mark A. Barber, Sarah Donald, Sylvia Thelen, Karen E. Anderson, Marcus Thelen, Heidi C. E. Welch

Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils: Nature Cell Biology

Sabine Suire, Alison M. Condliffe, G. John Ferguson, Chris D. Ellson, Hervé Guillou, Keith Davidson, Heidi Welch, John Coadwell, Martin Turner, Edwin R. Chilvers, Phillip T. Hawkins, Len Stephens

PI3K and RAC signalling in leukocyte and cancer cell migration

Mark A. Barber, Heidi C. E. Welch

Purification of P-Rex1 from neutrophils and nucleotide exchange assay

Kirsti Hill, Heidi C. E. Welch

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens

P-Rex1 Regulates Neutrophil Function

Heidi CE Welch, Alison M. Condliffe, Laura J. Milne, G. John Ferguson, Kirsti Hill, Louise MC Webb, Klaus Okkenhaug, W. John Coadwell, Simon R. Andrews, Marcus Thelen, Gareth E. Jones, Phillip T. Hawkins, Len R. Stephens

P-Rex2, a new guanine-nucleotide exchange factor for Rac

Sarah Donald, Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W. John Coadwell, Simon R. Andrews, Simon A. Walker, Phillip T. Hawkins, Len R. Stephens, Heidi C. E. Welch

Phosphoinositide 3‐kinase‐dependent activation of Rac

Heidi C.E. Welch, W.John Coadwell, Len R. Stephens, Phillip T. Hawkins

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

Heidi C. E. Welch, W. John Coadwell, Christian D. Ellson, G. John Ferguson, Simon R. Andrews, Hediye Erdjument-Bromage, Paul Tempst, Phillip T. Hawkins, Len R. Stephens

PI 3-kinase

Sonja Krugmann, Heidi Welch

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins

Expression of azurophil and specific granule proteins during differentiation of NB4 cells in neutrophils

C. Grégoire, H. Welch, C. Astarie-Dequeker, I. Maridonneau-Parini

Signalling via phosphoinositide 3OH kinases

P T Hawkins, H Welch, A McGregor, A Eguinoa, S Gobert, S Krugmann, K Anderson, D Stokoe, L Stephens

Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells

H. Welch, I. Maridonneau-Parini

Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes

H. Welch, I. Maridonneau-Parini