Animals

Removing physiological motion from intravital and clinical functional imaging data
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological …
Sean C. Warren, Max Nobis, Astrid Magenau, Yousuf H. Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James Rw Conway, Pauline Mélénec, Thomas R. Cox, Yingxiao Wang, Jennifer P. Morton, Heidi CE Welch, Douglas Strathdee, Kurt I. Anderson, Tri Giang Phan, Michael S. Roberts, Paul Timpson
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A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts
The small GTPase RhoA is involved in a variety of fundamental processes in normal tissue. Spatiotemporal control of RhoA is thought to …
Max Nobis, David Herrmann, Sean C. Warren, Shereen Kadir, Wilfred Leung, Monica Killen, Astrid Magenau, David Stevenson, Morghan C. Lucas, Nadine Reischmann, Claire Vennin, James Rw Conway, Alice Boulghourjian, Anaiis Zaratzian, Andrew M. Law, David Gallego-Ortega, Christopher J. Ormandy, Stacey N. Walters, Shane T. Grey, Jacqueline Bailey, Tatyana Chtanova, Julian MW Quinn, Paul A. Baldock, Peter I. Croucher, Juliane P. Schwarz, Agata Mrowinska, Lei Zhang, Herbert Herzog, Andrius Masedunskas, Edna C. Hardeman, Peter W. Gunning, Gonzalo Del Monte-Nieto, Richard P. Harvey, Michael S. Samuel, Marina Pajic, Ewan J. McGhee, Anna-Karin E. Johnsson, Owen J. Sansom, Heidi CE Welch, Jennifer P. Morton, Douglas Strathdee, Kurt I. Anderson, Paul Timpson
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Platelets in neutrophil recruitment to sites of inflammation
PURPOSE OF REVIEWThis review describes the essential roles of platelets in neutrophil recruitment from the bloodstream into inflamed …
Simon Pitchford, Dingxin Pan, Heidi CE Welch
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Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent …
Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi CE Welch
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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin
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Regulation and function of P-Rex family Rac-GEFs
The P-Rex family are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. They are distinguished from other …
Heidi CE Welch
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The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Numerous large scale genomics studies have demonstrated that cancer is a molecularly heterogeneous disease, characterized by acquired …
Marina Pajic, David Herrmann, Claire Vennin, James Rw Conway, Venessa T. Chin, Anna-Karin E. Johnsson, Heidi CE Welch, Paul Timpson
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A Rac1-Independent Role for P-Rex1 in Melanoblasts
Colin R. Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M. Machesky, Owen J. Sansom
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P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation
The small GTPase Rac is required for neutrophil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) …
Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, HeidiCE Welch
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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