Cells

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling
Integrin activation is essential for the function of leukocytes. Impaired integrin activation on leukocytes is the hallmark of the …
Jan M. Herter, Jan Rossaint, Helena Block, Heidi Welch, Alexander Zarbock
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the …
Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom
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Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells
We have previously shown that the src-family protein-tyrosine kinase Hck is localized on the azurophil granules of human granulocytes, …
H. Welch, I. Maridonneau-Parini
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Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes
Regulation of neutrophil responses is known to involve tyrosine phosphorylation. Hck, a major neutrophil protein-tyrosine kinase, …
H. Welch, I. Maridonneau-Parini
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