GTPase-Activating Proteins

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
INTRODUCTION: Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control …
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination
The small GTPase Rac controls cell morphology, gene expression, and reactive oxygen species formation. Manipulations of Rac activity …