Guanine Nucleotide Exchange Factors

Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase
Long-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly …
Claire Jackson, Heidi C. Welch, Tomas C. Bellamy
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Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that is directly activated by the betagamma subunits of …
Mark A. Barber, Sarah Donald, Sylvia Thelen, Karen E. Anderson, Marcus Thelen, Heidi C. E. Welch
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PI3K and RAC signalling in leukocyte and cancer cell migration
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …
Mark A. Barber, Heidi C. E. Welch
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Purification of P-Rex1 from neutrophils and nucleotide exchange assay
The P-Rex family of guanine-nucleotide exchange factors (GEFs) are activators of the small GTPase Rac (Donald et al., 2004; Rosenfeldt …
Kirsti Hill, Heidi C. E. Welch
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Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …
Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens
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