Human Beings

Platelets in neutrophil recruitment to sites of inflammation
PURPOSE OF REVIEWThis review describes the essential roles of platelets in neutrophil recruitment from the bloodstream into inflamed …
Simon Pitchford, Dingxin Pan, Heidi CE Welch
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Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent …
Dingxin Pan, Mark A. Barber, Kirsti Hornigold, Martin J. Baker, Judit M. Toth, David Oxley, Heidi CE Welch
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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin
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Regulation and function of P-Rex family Rac-GEFs
The P-Rex family are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. They are distinguished from other …
Heidi CE Welch
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The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment
Numerous large scale genomics studies have demonstrated that cancer is a molecularly heterogeneous disease, characterized by acquired …
Marina Pajic, David Herrmann, Claire Vennin, James Rw Conway, Venessa T. Chin, Anna-Karin E. Johnsson, Heidi CE Welch, Paul Timpson
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Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling
Integrin activation is essential for the function of leukocytes. Impaired integrin activation on leukocytes is the hallmark of the …
Jan M. Herter, Jan Rossaint, Helena Block, Heidi Welch, Alexander Zarbock
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Hck Is Activated by Opsonized Zymosan and A23187 in Distinct Subcellular Fractions of Human Granulocytes
Regulation of neutrophil responses is known to involve tyrosine phosphorylation. Hck, a major neutrophil protein-tyrosine kinase, …
H. Welch, I. Maridonneau-Parini
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The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation
The src-family protein-tyrosine kinase p59hck is mainly expressed in neutrophils; however, its functional role in these cells is …
H. Möhn, V. Le Cabec, S. Fischer, I. Maridonneau-Parini
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