Humans

Purification of P-Rex1 from neutrophils and nucleotide exchange assay
The P-Rex family of guanine-nucleotide exchange factors (GEFs) are activators of the small GTPase Rac (Donald et al., 2004; Rosenfeldt …
Kirsti Hill, Heidi C. E. Welch
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Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …
Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens
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P-Rex2, a new guanine-nucleotide exchange factor for Rac
We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It …
Sarah Donald, Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W. John Coadwell, Simon R. Andrews, Simon A. Walker, Phillip T. Hawkins, Len R. Stephens, Heidi C. E. Welch
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Expression of azurophil and specific granule proteins during differentiation of NB4 cells in neutrophils
Neutrophils contain several populations of secretory granules with characteristic sets of proteins. Granule proteins are sorted into …
C. Grégoire, H. Welch, C. Astarie-Dequeker, I. Maridonneau-Parini
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Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells
We have previously shown that the src-family protein-tyrosine kinase Hck is localized on the azurophil granules of human granulocytes, …
H. Welch, I. Maridonneau-Parini
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