Life Sciences

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin
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The src-family protein-tyrosine kinase p59hck is located on the secretory granules in human neutrophils and translocates towards the phagosome during cell activation
The src-family protein-tyrosine kinase p59hck is mainly expressed in neutrophils; however, its functional role in these cells is …
H. Möhn, V. Le Cabec, S. Fischer, I. Maridonneau-Parini
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