Mice

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B. Amin, Chia-Chin Wu, Kadir C. Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T. Arold, Heidi C. E. Welch, Levi A. Garraway, Lynda Chin
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A Rac1-Independent Role for P-Rex1 in Melanoblasts
Colin R. Lindsay, Ang Li, William Faller, Brad Ozanne, Heidi Welch, Laura M. Machesky, Owen J. Sansom
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P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation
The small GTPase Rac is required for neutrophil recruitment during inflammation, but its guanine-nucleotide exchange factor (GEF) …
Dingxin Pan, Richard T. Amison, Yanira Riffo-Vasquez, Domenico Spina, Simon J. Cleary, Michael J. Wakelam, Clive P. Page, Simon C. Pitchford, HeidiCE Welch
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling
Integrin activation is essential for the function of leukocytes. Impaired integrin activation on leukocytes is the hallmark of the …
Jan M. Herter, Jan Rossaint, Helena Block, Heidi Welch, Alexander Zarbock
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the …
Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom
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Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an amplitude …
Yanfeng Dai, Simon A. Walker, Edwin De Vet, Simon Cook, Heidi C. E. Welch, Peter J. Lockyer
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P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses
G protein-coupled receptor (GPCR) activation elicits neutrophil responses such as chemotaxis and reactive oxygen species (ROS) …
Campbell D. Lawson, Sarah Donald, Karen E. Anderson, Daniel T. Patton, Heidi C. E. Welch
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Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase
Long-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly …
Claire Jackson, Heidi C. Welch, Tomas C. Bellamy
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P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination
The small GTPase Rac controls cell morphology, gene expression, and reactive oxygen species formation. Manipulations of Rac activity …
Sarah Donald, Trevor Humby, Ian Fyfe, Anne Segonds-Pichon, Simon A. Walker, Simon R. Andrews, W. John Coadwell, Piers Emson, Lawrence S. Wilkinson, Heidi C. E. Welch
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