Heidi Welch Consulting
Heidi Welch Consulting
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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
PREX2 (phosphatidylinositol-3,4,5-triphosphate-dependent Rac-exchange factor 2) is a PTEN (phosphatase and tensin homolog deleted on …
Yonathan Lissanu Deribe
,
Yanxia Shi
,
Kunal Rai
,
Luigi Nezi
,
Samir B. Amin
,
Chia-Chin Wu
,
Kadir C. Akdemir
,
Mozhdeh Mahdavi
,
Qian Peng
,
Qing Edward Chang
,
Kirsti Hornigold
,
Stefan T. Arold
,
Heidi C. E. Welch
,
Levi A. Garraway
,
Lynda Chin
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Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities
CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an amplitude …
Yanfeng Dai
,
Simon A. Walker
,
Edwin De Vet
,
Simon Cook
,
Heidi C. E. Welch
,
Peter J. Lockyer
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DOI
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …
Kirsti Hill
,
Sonja Krugmann
,
Simon R. Andrews
,
W. John Coadwell
,
Peter Finan
,
Heidi C. E. Welch
,
Phillip T. Hawkins
,
Len R. Stephens
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