Heidi Welch Consulting
Heidi Welch Consulting
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Automatic
Neoplasm Invasiveness
PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis
The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression promotes …
Nuthasuda Srijakotre
,
Heng-Jia Liu
,
Max Nobis
,
Joey Man
,
Hon Yan Kelvin Yip
,
Antonella Papa
,
Helen E. Abud
,
Kurt I. Anderson
,
Heidi C. E. Welch
,
Tony Tiganis
,
Paul Timpson
,
Catriona A. McLean
,
Lisa M. Ooms
,
Christina A. Mitchell
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DOI
P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number …
Andrew D. Campbell
,
Samuel Lawn
,
Lynn C. McGarry
,
Heidi C. Welch
,
Bradford W. Ozanne
,
Jim C. Norman
Cite
DOI
PI3K and RAC signalling in leukocyte and cancer cell migration
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …
Mark A. Barber
,
Heidi C. E. Welch
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