Neoplasm Metastasis

PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis
The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression promotes …
Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, Christina A. Mitchell
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Removing physiological motion from intravital and clinical functional imaging data
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological …
Sean C. Warren, Max Nobis, Astrid Magenau, Yousuf H. Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James Rw Conway, Pauline Mélénec, Thomas R. Cox, Yingxiao Wang, Jennifer P. Morton, Heidi CE Welch, Douglas Strathdee, Kurt I. Anderson, Tri Giang Phan, Michael S. Roberts, Paul Timpson
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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P-Rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments
Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number …
Andrew D. Campbell, Samuel Lawn, Lynn C. McGarry, Heidi C. Welch, Bradford W. Ozanne, Jim C. Norman
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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the …
Colin R. Lindsay, Samuel Lawn, Andrew D. Campbell, William J. Faller, Florian Rambow, Richard L. Mort, Paul Timpson, Ang Li, Patrizia Cammareri, Rachel A. Ridgway, Jennifer P. Morton, Brendan Doyle, Shauna Hegarty, Mairin Rafferty, Ian G. Murphy, Enda W. McDermott, Kieran Sheahan, Katherine Pedone, Alexander J. Finn, Pamela A. Groben, Nancy E. Thomas, Honglin Hao, Craig Carson, Jim C. Norman, Laura M. Machesky, William M. Gallagher, Ian J. Jackson, Leon Van Kempen, Friedrich Beermann, Channing Der, Lionel Larue, Heidi C. Welch, Brad W. Ozanne, Owen J. Sansom
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PI3K and RAC signalling in leukocyte and cancer cell migration
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …
Mark A. Barber, Heidi C. E. Welch
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