Neutrophils

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
textlessptextgreaterRac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill …
Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch
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Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
INTRODUCTION: Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control …
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch
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Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses
Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to …
Kirsti Hornigold, Julia Y. Chu, Stephen A. Chetwynd, Polly A. Machin, Laraine Crossland, Chiara Pantarelli, Karen E. Anderson, Phillip T. Hawkins, Anne Segonds-Pichon, David Oxley, Heidi C. E. Welch
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Behavioural immune landscapes of inflammation
Transcriptional and proteomic profiling of individual cells have revolutionized interpretation of biological phenomena by providing …
Georgiana Crainiciuc, Miguel Palomino-Segura, Miguel Molina-Moreno, Jon Sicilia, David G. Aragones, Jackson Liang Yao Li, Rodrigo Madurga, José M. Adrover, Alejandra Aroca-Crevillén, Sandra Martin-Salamanca, Alfonso Serrano Del Valle, Sandra D. Castillo, Heidi C. E. Welch, Oliver Soehnlein, Mariona Graupera, Fátima Sánchez-Cabo, Alexander Zarbock, Thomas E. Smithgall, Mauro Di Pilato, Thorsten R. Mempel, Pierre-Louis Tharaux, Santiago F. González, Angel Ayuso-Sacido, Lai Guan Ng, Gabriel F. Calvo, Iván González-Díaz, Fernando Díaz-De-María, Andrés Hidalgo
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The GPCR adaptor protein norbin suppresses the neutrophil-mediated immunity of mice to pneumococcal infection
Streptococcal pneumonia is a worldwide health problem that kills ∼2 million people each year, particularly young children, the elderly, …
Chiara Pantarelli, Dingxin Pan, Stephen Chetwynd, Anne-Katrien Stark, Kirsti Hornigold, Polly Machin, Laraine Crossland, Simon J. Cleary, Martin J. Baker, Elizabeth Hampson, Anna Mandel, Anne Segonds-Pichon, Rachael Walker, Cornelis Van 'T Veer, Yanira Riffo-Vasquez, Klaus Okkenhaug, Simon Pitchford, Heidi C. E. Welch
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Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment
Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These …
Chiara Pantarelli, Heidi C. E. Welch
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses
G protein-coupled receptor (GPCR) activation elicits neutrophil responses such as chemotaxis and reactive oxygen species (ROS) …
Campbell D. Lawson, Sarah Donald, Karen E. Anderson, Daniel T. Patton, Heidi C. E. Welch
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Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase
Long-term potentiation (LTP) at the parallel fibre-Purkinje cell synapse in the cerebellum is a recently described and poorly …
Claire Jackson, Heidi C. Welch, Tomas C. Bellamy
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Gβγs and the Ras binding domain of p110γ are both important regulators of PI3Kγ signalling in neutrophils: Nature Cell Biology
Through their ability to regulate production of the key lipid messenger PtdIns(3,4,5)P3, the class I phosphatidylinositol-3-OH kinases …
Sabine Suire, Alison M. Condliffe, G. John Ferguson, Chris D. Ellson, Hervé Guillou, Keith Davidson, Heidi Welch, John Coadwell, Martin Turner, Edwin R. Chilvers, Phillip T. Hawkins, Len Stephens
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