Phosphatidylinositol 3-Kinases

Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G …
C. D. Lawson, K. Hornigold, D. Pan, I. Niewczas, S. Andrews, J. Clark, Hce Welch
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Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that is directly activated by the betagamma subunits of …
Mark A. Barber, Sarah Donald, Sylvia Thelen, Karen E. Anderson, Marcus Thelen, Heidi C. E. Welch
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PI3K and RAC signalling in leukocyte and cancer cell migration
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …
Mark A. Barber, Heidi C. E. Welch
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Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth …
H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins
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