Point Mutation

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …
Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens
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Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth …
H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins
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