Rac

The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
textlessptextgreaterRac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill …
Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch
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Functions and mechanisms of the GPCR adaptor protein Norbin
Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century …
Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch
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Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis
INTRODUCTION: Rac-GTPases and their Rac-GEF activators play important roles in neutrophil-mediated host defence. These proteins control …
Polly A. Machin, Anna-Karin E. Johnsson, Ellie J. Massey, Chiara Pantarelli, Stephen A. Chetwynd, Julia Y. Chu, Hanneke Okkenhaug, Anne Segonds-Pichon, Simon Walker, Angeliki Malliri, Yoshinori Fukui, Heidi C. E. Welch
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Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G …
C. D. Lawson, K. Hornigold, D. Pan, I. Niewczas, S. Andrews, J. Clark, Hce Welch
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