Recombinant Proteins

Purification of P-Rex1 from neutrophils and nucleotide exchange assay
The P-Rex family of guanine-nucleotide exchange factors (GEFs) are activators of the small GTPase Rac (Donald et al., 2004; Rosenfeldt …
Kirsti Hill, Heidi C. E. Welch
Cite DOI
Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits
P-Rex1 is a guanine-nucleotide exchange factor (GEF) for the small GTPase Rac. We have investigated here the mechanisms of stimulation …
Kirsti Hill, Sonja Krugmann, Simon R. Andrews, W. John Coadwell, Peter Finan, Heidi C. E. Welch, Phillip T. Hawkins, Len R. Stephens
Cite DOI
P-Rex2, a new guanine-nucleotide exchange factor for Rac
We have identified a new guanine-nucleotide exchange factor, P-Rex2, and cloned it from human skeletal muscle and brain libraries. It …
Sarah Donald, Kirsti Hill, Charlotte Lecureuil, Romain Barnouin, Sonja Krugmann, W. John Coadwell, Simon R. Andrews, Simon A. Walker, Phillip T. Hawkins, Len R. Stephens, Heidi C. E. Welch
Cite DOI