Heidi Welch Consulting
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Rho GEF
Small-molecule inhibitors of P-Rex guanine-nucleotide exchange factors
P-Rex1 and P-Rex2 are guanine-nucleotide exchange factors (GEFs) that activate Rac small GTPases in response to the stimulation of G …
C. D. Lawson
,
K. Hornigold
,
D. Pan
,
I. Niewczas
,
S. Andrews
,
J. Clark
,
Hce Welch
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DOI
Rho Family GTPases and Rho GEFs in Glucose Homeostasis
Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health …
Polly A. Machin
,
Elpida Tsonou
,
David C. Hornigold
,
Heidi C. E. Welch
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DOI
P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis
,
Laure Gambardella
,
Kent L. Rossman
,
Campbell D. Lawson
,
Karen E. Anderson
,
Yoshinori Fukui
,
Heidi C. Welch
,
Channing J. Der
,
Len R. Stephens
,
Phillip T. Hawkins
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DOI
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