Signal Transduction

Functions and mechanisms of the GPCR adaptor protein Norbin
Norbin (Neurochondrin, NCDN) is a highly conserved 79 kDa adaptor protein that was first identified more than a quarter of a century …
Stephen A. Chetwynd, Simon Andrews, Sarah Inglesfield, Christine Delon, Nicholas T. Ktistakis, Heidi C. E. Welch
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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing …
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C. E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
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P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range …
Elizabeth Hampson, Elpida Tsonou, Martin J. Baker, David C. Hornigold, Roderick E. Hubbard, Andrew Massey, Heidi C. E. Welch
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Rac-GTPases and Rac-GEFs in neutrophil adhesion, migration and recruitment
Rac-GTPases and their Rac-GEF activators play important roles in the recruitment and host defence functions of neutrophils. These …
Chiara Pantarelli, Heidi C. E. Welch
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P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils
G-protein-coupled receptors (GPCRs) regulate the organisation of the actin cytoskeleton by activating the Rac subfamily of small …
George Damoulakis, Laure Gambardella, Kent L. Rossman, Campbell D. Lawson, Karen E. Anderson, Yoshinori Fukui, Heidi C. Welch, Channing J. Der, Len R. Stephens, Phillip T. Hawkins
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PI3K and RAC signalling in leukocyte and cancer cell migration
Leukocytes and amoeboid-stage cancer cells migrate in a similar manner. Key signalling molecules regulating leukocyte and cancer cell …
Mark A. Barber, Heidi C. E. Welch
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Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
The GTPase Rac and the protein kinase B (PKB) are downstream targets of phosphatidylinositide 3OH-kinase in platelet-derived growth …
H. Welch, A. Eguinoa, L. R. Stephens, P. T. Hawkins
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Lyn and Fgr are activated in distinct membrane fractions of human granulocytic cells
We have previously shown that the src-family protein-tyrosine kinase Hck is localized on the azurophil granules of human granulocytes, …
H. Welch, I. Maridonneau-Parini
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